Despite all these giant high quality studies published in peer-reviewed medical journals, the expert organizations keep on singing the old song of low fat diet with saturated fat less than 10% of total calorie. Old dogmas die hard and we must keep on fighting outdated guidelines from organizations with huge conflicts of interest.
PURE study is an international prospective epidemiolgy study involving 18 countries with a median follow-up of 7·4 years. Just as in Women's Health Initiative which is another huge study showing low fat diet fails, PURE study shows once again that intake of total fat and each type of fat was associated with lower risk of total mortality (quintile 5 vs quintile 1, total fat: HR 0·77 [95% CI 0·67-0·87], ptrend<0·0001; saturated fat, HR 0·86 [0·76-0·99], ptrend=0·0088; monounsaturated fat: HR 0·81 [0·71-0·92], p trend<0·0001; and polyunsaturated fat: HR 0·80 [0·71-0·89], p trend<0·0001). Higher saturated fat intake was associated with lower risk of stroke (quintile 5 vs quintile 1, HR 0·79 [95% CI 0·64-0·98], p trend=0·0498). Total fat and saturated and unsaturated fats were not significantly associated with risk of myocardial infarction or cardiovascular disease mortality. This is totally in contrast to Ancel Key's Seven country study which started the low-fat mania 3 decades ago.
Despite all these giant high quality studies published in peer-reviewed medical journals, the expert organizations keep on singing the old song of low fat diet with saturated fat less than 10% of total calorie. Old dogmas die hard and we must keep on fighting outdated guidelines from organizations with huge conflicts of interest.
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