The key principle is that carbohydrate, directly or indirectly, through insulin and other hormones, controls what happens to ingested fatty acids. Carbohydrate is catalytic, that is, exerts its effect on other nutrients. The fat in the big Mac will not constitute any risk if you chuck the bun. Scientific evidence shows that dietary saturated fat, in general, has no effect on cardiovascular disease, obesity or probably anything else, but plasma saturated fatty acids do have effects. If you study dietary saturated fatty acids under conditions where carbohydrate is high or, more important, if you study effects in rodents where plasma fat better correlates with dietary fat, then you will confuse plasma fat with dietary fat. In humans, as opposed to rodents, saturated fatty acid in your blood is not equivalent to saturated fatty acid on your plate! In other words, if you eat high saturated fat diet & carb content is low, your plasma saturated fat will not rise. Lipophobes often cite rodent studies in which plasma saturated fat increase when they consume high saturated fat diet. You cannot extrapolate rodent data to humans in this respect!
The following is extracted from a Biochemists's book:
The key principle is that carbohydrate, directly or indirectly, through insulin and other hormones, controls what happens to ingested fatty acids. Carbohydrate is catalytic, that is, exerts its effect on other nutrients. The fat in the big Mac will not constitute any risk if you chuck the bun. Scientific evidence shows that dietary saturated fat, in general, has no effect on cardiovascular disease, obesity or probably anything else, but plasma saturated fatty acids do have effects. If you study dietary saturated fatty acids under conditions where carbohydrate is high or, more important, if you study effects in rodents where plasma fat better correlates with dietary fat, then you will confuse plasma fat with dietary fat. In humans, as opposed to rodents, saturated fatty acid in your blood is not equivalent to saturated fatty acid on your plate! In other words, if you eat high saturated fat diet & carb content is low, your plasma saturated fat will not rise. Lipophobes often cite rodent studies in which plasma saturated fat increase when they consume high saturated fat diet. You cannot extrapolate rodent data to humans in this respect!
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