In the above article, two studies suggest that current habitual consumption of 51%-carbohydrate diets in the US may increase fasting insulin resistance in a clinically relevant way and promote body fat accumulation by reducing lipolysis and fat oxidation through stimulation by the high post- prandial insulin concentrations of the adipose tissue lipoprotein lipase. This study using acute one-day alteration of dietary carbohydrate content and the two studies extending it to between 5 and 14 days suggest that a reduction of carbohydrate content of the meals from about 60% to about 30% of daily energy may substantially reduce this potential risk.
Meal containing 60%Carb may cause higher evening postprandial insulin spike than 30%Carb meal25/2/2017 A study published in Plos one in 2016 tried to find out whether carb content matters in regard to postprandial insulin response in the evening. It is unclear whether the rise in Type 2DM incidence from 4.4 million or 2.4% of the US population in 1970s to 29.1 million or 9.3% of the population in 2014 may have been facilitated by a 30.5% increase in daily carbohydrate consumption from 213 g per day in 1965 to 278 g per day or 51% of daily calories in 2011. The currently high carbohydrate consumption falls within the 45 to 65% of daily calorie range recommended in 2010 by Departments of Agriculture and Health and Human Services. This study explores the extent to which the recommended high daily carbohydrate intake contributes to evening postprandial glucose intolerance. Postprandial hyperglycemia and delayed or protracted hyperinsulinemia are prevalent in metabolically healthy individuals in the evening but not in the morning when the same carbohydrate load is delivered as oral glucose, a carbohydrate-containing meal, or as intravenous glucose injection. Insulin hypoglycemic action for the same carbohydrate load also is lower in the evening than in the morning as shown by the requirement for a higher evening dose of insulin secretagogue tolbutamide and of insulin in type 1 diabetics. A circadian influence was recently implicated in the reduced β cell capacity to secrete insulin in the evening. However, neither this study nor two others [20,21] eliminated the possibility that the evening post- prandial hyperglycemia and delayed or protracted hyperinsulinemia result from the large daily cumulative carbohydrate load.
In the above article, two studies suggest that current habitual consumption of 51%-carbohydrate diets in the US may increase fasting insulin resistance in a clinically relevant way and promote body fat accumulation by reducing lipolysis and fat oxidation through stimulation by the high post- prandial insulin concentrations of the adipose tissue lipoprotein lipase. This study using acute one-day alteration of dietary carbohydrate content and the two studies extending it to between 5 and 14 days suggest that a reduction of carbohydrate content of the meals from about 60% to about 30% of daily energy may substantially reduce this potential risk.
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