In both Paris Prospective study and Whitehall Study, as shown below, mortality in undiagnosed as well as diagnosed DM pts is more than 2 fold that of nondiabetic persons. Therefore, it is clear that undiagnosed DM is as deadly as diagnosed DM. Kraft's OGT with insulin assay can capture earliest DM (ie. DM in situ), at least 10 yrs earlier than fasting glucose or routine OGTT which measures glucose only.
Onset of NIDDM probably occurs at least 12 yrs before its clinical diagnosis. 21% of newly diagnosed pts have retinopathy. Undiagnosed NIDDM is not a benign condition. The prevalence of macrovascular disease in undiagnosed NIDDM is about equal to that found in diagnosed DM, & rates of CHD in both diagnosed and undiagnosed DM are about twice that for nondiabetic individuals. Mortality in undiagnosed DM is also equal to that of diagnosed DM, and both are significantly higher than in nondiabetic individuals.
In both Paris Prospective study and Whitehall Study, as shown below, mortality in undiagnosed as well as diagnosed DM pts is more than 2 fold that of nondiabetic persons. Therefore, it is clear that undiagnosed DM is as deadly as diagnosed DM. Kraft's OGT with insulin assay can capture earliest DM (ie. DM in situ), at least 10 yrs earlier than fasting glucose or routine OGTT which measures glucose only.
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